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Statements


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"We further characterized the immune response induced by the formulation that provided the highest protection against invasive lethal challenge and compared it to the immune response induced by Combo5 / alum and M1/alum."
SMQ activates TNF-α. 1
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"A comparison between the cytokine concentrations secreted by splenocytes from Combo5 / alum and Combo5 / SMQ immune mice showed that the SMQ adjuvanted formulation induced significantly higher secretion of IL-6, IL-10, IFN-γ, and TNF-α than the alum adjuvanted formulation."
SMQ activates IL6. 1
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"A comparison between the cytokine concentrations secreted by splenocytes from Combo5 / alum and Combo5 / SMQ immune mice showed that the SMQ adjuvanted formulation induced significantly higher secretion of IL-6, IL-10, IFN-γ, and TNF-α than the alum adjuvanted formulation."
SMQ activates IL10. 1
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"A comparison between the cytokine concentrations secreted by splenocytes from Combo5 / alum and Combo5 / SMQ immune mice showed that the SMQ adjuvanted formulation induced significantly higher secretion of IL-6, IL-10, IFN-γ, and TNF-α than the alum adjuvanted formulation."
SMQ activates IFN-γ. 1
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"A comparison between the cytokine concentrations secreted by splenocytes from Combo5 / alum and Combo5 / SMQ immune mice showed that the SMQ adjuvanted formulation induced significantly higher secretion of IL-6, IL-10, IFN-γ, and TNF-α than the alum adjuvanted formulation."
GS26575 activates GAST. 1
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"Only M1 immune sera was able to promote opsonophagocytic killing of GAS (XREF_FIG) with an opsonic index significantly higher than that measured for naive mice."
Combo5 activates immune response. 1
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"We further characterized the protective immune response elicited by Combo5 formulated with SMQ adjuvant and compared this to the nonprotective response elicited by Combo5 / alum and to the protective response elicited by the “ gold standard ” homologous M1 protein formulated with alum."